Description
ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 190714-28-4
Molecular Weight: 930.07
Formula: C49H52N3NaO10S2
Chemical Name: sodium 2-[(1E,3E,5E)-7-[(2Z)-1,1-dimethyl-3-(4-sulfonatobutyl)-1H,2H,3H-benzo[e]indol-2-ylidene]hepta-1,3,5-trien-1-yl]-3-{6-[(2,5-dioxo-3-sulfonatopyrrolidin-1-yl)oxy]-6-oxohexyl}-1,1-dimethyl-1H-benzo[e]indol-3-ium
Smiles: [Na+].CC1(C)C2C(=CC=C3C=CC=CC3=2)[N+](CCCCCC(=O)ON2C(=O)C(CC2=O)S([O-])(=O)=O)=C1/C=C/C=C/C=C/C=C1\N(CCCCS([O-])(=O)=O)C2=CC=C3C=CC=CC3=C2C\1(C)C
InChiKey: PUIWPNXPCPENEL-UHFFFAOYSA-M
InChi: InChI=1S/C49H53N3O10S2.Na/c1-48(2)41(23-9-6-5-7-10-24-42-49(3,4)46-37-22-15-13-20-35(37)27-29-39(46)51(42)31-17-18-32-63(56,57)58)50(38-28-26-34-19-12-14-21-36(34)45(38)48)30-16-8-11-25-44(54)62-52-43(53)33-40(47(52)55)64(59,60)61;/h5-7,9-10,12-15,19-24,26-29,40H,8,11,16-18,25,30-33H2,1-4H3,(H-,56,57,58,59,60,61);/q;+1/p-1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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