Amino-PEG3-C2-Azido


Catalog No. Size PriceQuantity
M32451-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645).

Product information

CAS Number: 134179-38-7

Molecular Weight: 218.25

Formula: C8H18N4O3

Chemical Name: 1-[2-(2-aminoethoxy)ethoxy]-2-(2-azidoethoxy)ethane

Smiles: [N-]=[N+]=NCCOCCOCCOCCN

InChiKey: FPVCVHVTMPCZTH-UHFFFAOYSA-N

InChi: InChI=1S/C8H18N4O3/c9-1-3-13-5-7-15-8-6-14-4-2-11-12-10/h1-9H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation.

Products are for research use only. Not for human use.

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