Description
DBCO-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 1839049-33-0
Molecular Weight: 348.40
Formula: C21H20N2O3
Chemical Name: 4-{2-azatricyclo[10.4.0.0⁴,⁹]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-N-(2-hydroxyethyl)-4-oxobutanamide
Smiles: OCCNC(=O)CCC(=O)N1CC2=CC=CC=C2C#CC2=CC=CC=C12
InChiKey: KCIDEKJZCAKKOQ-UHFFFAOYSA-N
InChi: InChI=1S/C21H20N2O3/c24-14-13-22-20(25)11-12-21(26)23-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)23/h1-8,24H,11-15H2,(H,22,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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