Description
endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 1263166-91-1
Molecular Weight: 315.32
Formula: C17H17NO5
Chemical Name: [(1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl]methyl 4-nitrophenyl carbonate
Smiles: [O-][N+](=O)C1=CC=C(C=C1)OC(=O)OCC1[C@H]2CCC#CCC[C@H]21
InChiKey: QXNXOXMDBLHIDB-XYPWUTKMSA-N
InChi: InChI=1S/C17H17NO5/c19-17(23-13-9-7-12(8-10-13)18(20)21)22-11-16-14-5-3-1-2-4-6-15(14)16/h7-10,14-16H,3-6,11H2/t14-,15+,16?
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Products are for research use only. Not for human use.
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