Description
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.
Product information
CAS Number: 1361217-07-3
Molecular Weight: 519.60
Formula: C22H28F3N3O4S2
Chemical Name: 1,1,1-trifluoro-2-{4-[(2S)-2-[(morpholin-4-yl)methyl]-4-(thiophene-2-sulfonyl)piperazin-1-yl]phenyl}propan-2-ol
Smiles: CC(O)(C1C=CC(=CC=1)N1CCN(C[C@@H]1CN1CCOCC1)S(=O)(=O)C1=CC=CS1)C(F)(F)F
InChiKey: VBLZIQWKNALQNL-ZQRQZVKFSA-N
InChi: InChI=1S/C22H28F3N3O4S2/c1-21(29,22(23,24)25)17-4-6-18(7-5-17)28-9-8-27(34(30,31)20-3-2-14-33-20)16-19(28)15-26-10-12-32-13-11-26/h2-7,14,19,29H,8-13,15-16H2,1H3/t19-,21?/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP.
Products are for research use only. Not for human use.
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