Description
DiOC6(3) iodide, CAS No. 53213-82-4, Synonyms 3, 3'-Dihexyloxacarbocyanine iodide, is a carbocyanine dye which can be used to monitor changes in mitochondrial membrane potential.
Product information
CAS Number: 53213-82-4
Molecular Weight: 572.52
Formula: C29H37IN2O2
Synonym:
3, 3'-Dihexyloxacarbocyanine iodide
Chemical Name: 3-hexyl-2-[(1E)-3-[(2Z)-3-hexyl-2,3-dihydro-1,3-benzoxazol-2-ylidene]prop-1-en-1-yl]-1,3-benzoxazol-3-ium iodide
Smiles: [I-].CCCCCC[N+]1C2=CC=CC=C2OC=1/C=C/C=C1\OC2=CC=CC=C2N\1CCCCCC
InChiKey: XVLXYDXJEKLXHN-UHFFFAOYSA-M
InChi: InChI=1S/C29H37N2O2.HI/c1-3-5-7-13-22-30-24-16-9-11-18-26(24)32-28(30)20-15-21-29-31(23-14-8-6-4-2)25-17-10-12-19-27(25)33-29;/h9-12,15-21H,3-8,13-14,22-23H2,1-2H3;1H/q+1;/p-1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (87.33 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Addition of cells to the cuvette containing 0.25 μM 3,3'-Dihexyloxacarbocyanine iodide (DiOCg(3)) leads to an increase in fluorescence, equilibration is rapid and is complete by 4 min. When f-met-leu-phe (10-7 M) is added to neutrophils preequilibrated with 3,3'-Dihexyloxacarbocyanine iodide, there is a short lag period of 5 seconds. The lag period is followed by a rapid loss of fluorescence. Examination of 3,3'-Dihexyloxacarbocyanine iodide loaded neutrophils using fluorescence microscopy demonstrates that in resting neutrophils the brightest fluorescence is associated with long thin organelles which corresponds to the distribution of mitochondria.
Products are for research use only. Not for human use.
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