Description
DC4, an ADC cytotoxin, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC4 can be used for the targeted treatment of cancer.
Product information
CAS Number: 615538-48-2
Molecular Weight: 718.12
Formula: C34H29ClN5O7PS
Chemical Name: {[(1S)-1-(chloromethyl)-3-{5-[5-(3-sulfanylpropanamido)-1H-indole-2-amido]-1H-indole-2-carbonyl}-1H,2H,3H-benzo[e]indol-5-yl]oxy}phosphonic acid
Smiles: OP(O)(=O)OC1=CC2=C([C@H](CCl)CN2C(=O)C2=CC3=CC(=CC=C3N2)NC(=O)C2=CC3=CC(=CC=C3N2)NC(=O)CCS)C2=CC=CC=C21
InChiKey: PWGCKOQNKYABMN-HXUWFJFHSA-N
InChi: InChI=1S/C34H29ClN5O7PS/c35-16-20-17-40(29-15-30(47-48(44,45)46)23-3-1-2-4-24(23)32(20)29)34(43)28-14-19-12-22(6-8-26(19)39-28)37-33(42)27-13-18-11-21(5-7-25(18)38-27)36-31(41)9-10-49/h1-8,11-15,20,38-39,49H,9-10,16-17H2,(H,36,41)(H,37,42)(H2,44,45,46)/t20-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DC4 can be conjugated to the humanized monoclonal antibody huB4 and huC242 by a linker SPP, SPDB, and SMCC to form huB4-SPP-DC44, huC242-SPDB-DC4, huC242-SPP-DC4, and huC242-SMCC-DC4.
Products are for research use only. Not for human use.
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