Description
DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC50 of 10 μM.
Product information
CAS Number: 675104-49-1
Molecular Weight: 308.38
Formula: C12H12N4O2S2
Chemical Name: 3-{[(2-nitrophenyl)sulfanyl]methyl}-4-(prop-2-en-1-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thione
Smiles: C=CCN1C(=S)NN=C1CSC1=CC=CC=C1[N+]([O-])=O
InChiKey: VWFIHGWHMXSTAO-UHFFFAOYSA-N
InChi: InChI=1S/C12H12N4O2S2/c1-2-7-15-11(13-14-12(15)19)8-20-10-6-4-3-5-9(10)16(17)18/h2-6H,1,7-8H2,(H,14,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (810.69 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DSHS00884 stabilizes p53 levels in HPV-positive cells by blocking E6-mediated p53 degradation with an IC50 of 2.5-25 μM.
Products are for research use only. Not for human use.
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