Description
K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).
Product information
CAS Number: 872201-12-2
Molecular Weight: 393.27
Formula: C22H17BrO2
Chemical Name: 4-[(E)-2-{3-bromo-4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl}ethenyl]phenol
Smiles: OC1C=CC(/C=C/C2C=C(Br)C(/C=C/C3C=CC(O)=CC=3)=CC=2)=CC=1
InChiKey: OXPHQQMZTXMEGO-RJTULKDBSA-N
InChi: InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (254.28 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
K114's unusually low buffer fluorescence is due to self-quenching in sedimentable aggregates or micelles which upon interacting with amyloid fibrils undergo an enhancement in fluorescence intensity and shifts in the excitation and emission spectra.
Products are for research use only. Not for human use.
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