SMIFH2


Catalog No. Size PriceQuantity
M32907-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton.

Product information

CAS Number: 340316-62-3

Molecular Weight: 377.21

Formula: C15H9BrN2O3S

Chemical Name: (5E)-1-(3-bromophenyl)-5-[(furan-2-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione

Smiles: O=C1/C(=C/C2=CC=CO2)/C(=O)NC(=S)N1C1=CC(Br)=CC=C1

InChiKey: MVFJHEQDISFYIS-XYOKQWHBSA-N

InChi: InChI=1S/C15H9BrN2O3S/c16-9-3-1-4-10(7-9)18-14(20)12(13(19)17-15(18)22)8-11-5-2-6-21-11/h1-8H,(H,17,19,22)/b12-8+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells. SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner. SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton.

Products are for research use only. Not for human use.

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