AP-C5


Catalog No. Size PriceQuantity
M32914-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease.

Product information

CAS Number: 2234272-10-5

Molecular Weight: 275.31

Formula: C16H13N5

Chemical Name: 4-[4-(1H-imidazol-1-yl)phenyl]-N-(prop-2-yn-1-yl)pyrimidin-2-amine

Smiles: C#CCNC1=NC(=CC=N1)C1C=CC(=CC=1)N1C=NC=C1

InChiKey: QKHQFSQJQKGFAA-UHFFFAOYSA-N

InChi: InChI=1S/C16H13N5/c1-2-8-18-16-19-9-7-15(20-16)13-3-5-14(6-4-13)21-11-10-17-12-21/h1,3-7,9-12H,8H2,(H,18,19,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue. AP-C5 potentiates cAMP signaling by PDE inhibition. AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed