Cyclic ADP-ribose


Catalog No. Size PriceQuantity
M32927-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.

Product information

CAS Number: 119340-53-3

Molecular Weight: 541.30

Formula: C15H21N5O13P2

Chemical Name: (2R,3R,4S,5R,13R,14S,15R,16R)-3,4,8,10,14,15-hexahydroxy-24-imino-7,9,11,25,26-pentaoxa-1,17,19,22-tetraaza-8λ⁵,10λ⁵-diphosphapentacyclo[18.3.1.1²,⁵.1¹³,¹⁶.0¹⁷,²¹]hexacosa-18,20,22-triene-8,10-dione

Smiles: N=C1C2N=CN3[C@@H]4O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]5O[C@H]([C@H](O)[C@@H]5O)N1C=NC3=2)[C@@H](O)[C@H]4O

InChiKey: BQOHYSXSASDCEA-KEOHHSTQSA-N

InChi: InChI=1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates. cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes. cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture.

In Vivo:

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice.

Products are for research use only. Not for human use.

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