Description
CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM.
Product information
CAS Number: 2093317-51-0
Molecular Weight: 312.40
Formula: C18H17FN2S
Chemical Name: 12-fluoro-5-[(4-methylpyridin-3-yl)methyl]-8-thia-5-azatricyclo[7.4.0.0²,⁷]trideca-1(13),2(7),9,11-tetraene
Smiles: CC1=CC=NC=C1CN1CC2SC3=CC=C(F)C=C3C=2CC1
InChiKey: ATNGVPCHSCNOMP-UHFFFAOYSA-N
InChi: InChI=1S/C18H17FN2S/c1-12-4-6-20-9-13(12)10-21-7-5-15-16-8-14(19)2-3-17(16)22-18(15)11-21/h2-4,6,8-9H,5,7,10-11H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4.
In Vivo:
CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats.
Products are for research use only. Not for human use.
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