Description
FTBMT is a selective GPR52 agonist with an EC50 of 75 nM. FTBMT has antipsychotic and procognitive properties.
Product information
CAS Number: 1358575-02-6
Molecular Weight: 392.35
Formula: C19H16F4N4O
Chemical Name: 4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
Smiles: CC1=NC(CC2=CC(F)=CC(=C2)C(F)(F)F)=NN1C1C=C(C)C(=CC=1)C(N)=O
InChiKey: TYXSIXOYTBHZFA-UHFFFAOYSA-N
InChi: InChI=1S/C19H16F4N4O/c1-10-5-15(3-4-16(10)18(24)28)27-11(2)25-17(26-27)8-12-6-13(19(21,22)23)9-14(20)7-12/h3-7,9H,8H2,1-2H3,(H2,24,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (254.87 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively.
In Vivo:
FTBMT (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.
Products are for research use only. Not for human use.
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