Fosnetupitant


Catalog No. Size PriceQuantity
M33030-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor.

Product information

CAS Number: 1703748-89-3

Molecular Weight: 688.60

Formula: C31H35F6N4O5P

Chemical Name: 4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(2-methylphenyl)pyridin-2-yl)-1-[(hydrogen phosphonatooxy)methyl]-1-methylpiperazin-1-ium

Smiles: CC(C)(C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(=O)N(C)C1=CN=C(C=C1C1=CC=CC=C1C)N1CC[N+](C)(COP([O-])(O)=O)CC1

InChiKey: HZIYEEMJNBKMJH-UHFFFAOYSA-N

InChi: InChI=1S/C31H35F6N4O5P/c1-20-8-6-7-9-24(20)25-17-27(40-10-12-41(5,13-11-40)19-46-47(43,44)45)38-18-26(25)39(4)28(42)29(2,3)21-14-22(30(32,33)34)16-23(15-21)31(35,36)37/h6-9,14-18H,10-13,19H2,1-5H3,(H-,43,44,45)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated.

In Vivo:

Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats.

Products are for research use only. Not for human use.

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