XPC-6444

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity.

Product information

CAS Number: 2230144-21-3

Molecular Weight: 498.58

Formula: C22H25F3N4O2S2

Chemical Name: 4-{[(2-{[tert-butyl(methyl)amino]methyl}-6-fluorophenyl)methyl]amino}-2,6-difluoro-N-(1,3-thiazol-4-yl)benzene-1-sulfonamide

Smiles: CN(CC1=CC=CC(F)=C1CNC1=CC(F)=C(C(F)=C1)S(=O)(=O)NC1=CSC=N1)C(C)(C)C

InChiKey: VOJFVKGTRNXOTJ-UHFFFAOYSA-N

InChi: InChI=1S/C22H25F3N4O2S2/c1-22(2,3)29(4)11-14-6-5-7-17(23)16(14)10-26-15-8-18(24)21(19(25)9-15)33(30,31)28-20-12-32-13-27-20/h5-9,12-13,26,28H,10-11H2,1-4H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

XPC-6444 shows high selectivity over NaV1.1 and NaV1.5.

In Vivo:

XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux.

Products are for research use only. Not for human use.