Cimetidine sulfoxide


Catalog No. Size PriceQuantity
M33319-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment.

Product information

CAS Number: 54237-72-8

Molecular Weight: 268.34

Formula: C10H16N6OS

Chemical Name: N-cyano-N''-methyl-N'-{2-[(5-methyl-1H-imidazol-4-yl)methanesulfinyl]ethyl}guanidine

Smiles: CC1NC=NC=1CS(=O)CCNC(NC#N)=NC

InChiKey: HOJLJLYVNQFCRE-UHFFFAOYSA-N

InChi: InChI=1S/C10H16N6OS/c1-8-9(16-7-15-8)5-18(17)4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations.

In Vivo:

The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/−) 57:43.

Products are for research use only. Not for human use.

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