Description
CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis.
Product information
CAS Number: 2416095-00-4
Molecular Weight: 402.27
Formula: C12H13Cl2NO6S2
Chemical Name: 2-{[(3S,4R)-4-(3,4-dichlorobenzenesulfonyl)-1,1-dioxo-1λ⁶-thiolan-3-yl]amino}acetic acid
Smiles: OC(=O)CN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1
InChiKey: FNQDSYKGBCVHHI-QWRGUYRKSA-N
InChi: InChI=1S/C12H13Cl2NO6S2/c13-8-2-1-7(3-9(8)14)23(20,21)11-6-22(18,19)5-10(11)15-4-12(16)17/h1-3,10-11,15H,4-6H2,(H,16,17)/t10-,11-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 200 mg/mL (497.18 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts.
In Vivo:
CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo.
Products are for research use only. Not for human use.
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