SK33


Catalog No. Size PriceQuantity
M33351-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity.

Product information

CAS Number: 1928724-23-5

Molecular Weight: 500.31

Formula: C20H13F9N2O3

Chemical Name: 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

Smiles: CC(O)(COC1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F

InChiKey: VJIVKRQGSGBLFP-UHFFFAOYSA-N

InChi: InChI=1S/C20H13F9N2O3/c1-17(33,16(32)31-13-3-2-10(8-30)15(7-13)20(27,28)29)9-34-14-5-11(18(21,22)23)4-12(6-14)19(24,25)26/h2-7,33H,9H2,1H3,(H,31,32)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33.

In Vivo:

SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity.

Products are for research use only. Not for human use.

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