Description
BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively.
Product information
CAS Number: 1551403-51-0
Molecular Weight: 364.44
Formula: C21H24N4O2
Chemical Name: 8-{[(2S)-2-amino-4-methylpentyl]oxy}-4,6-dimethyl-5-oxo-5H,6H-benzo[c]2,7-naphthyridine-9-carbonitrile
Smiles: CC1=NC=CC2=C1C(=O)N(C)C1=CC(OC[C@@H](N)CC(C)C)=C(C=C21)C#N
InChiKey: NQXBZPJVVGIFBJ-HNNXBMFYSA-N
InChi: InChI=1S/C21H24N4O2/c1-12(2)7-15(23)11-27-19-9-18-17(8-14(19)10-22)16-5-6-24-13(3)20(16)21(26)25(18)4/h5-6,8-9,12,15H,7,11,23H2,1-4H3/t15-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BMT-090605 shows a cellular IC50 of 0.63 ±0.39 nM for AAK1.
In Vivo:
BMT-090605 (0.3-3 µg/rat; intrathecally at lumbar level L5/L6) causes antinociception by inhibiting AAK1 in the spinal cord. The high dose of BMT-090605 (3 µg/rat) showed efficacy comparable to intrathecal clonidine (3 µg/rat). Exposure measurements from this study indicated that brain and plasma levels of BMT-090605 were <4 nM, whereas measurable levels (90–317 nM) were observed in lumbar spinal cord.
Products are for research use only. Not for human use.
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