Description
GPS491 (EC50 = 0.47 μM) suppresses expression of the HIV-1 structural protein Gag and alters HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins.
Product information
CAS Number: 2655502-29-5
Molecular Weight: 397.32
Formula: C13H5F6N3OS2
Chemical Name: 2-(trifluoromethyl)-N-[6-(trifluoromethyl)-1, 3-benzothiazol-2-yl]-1, 3-thiazole-5-carboxamide
Smiles: O=C(NC1=NC2=CC=C(C=C2S1)C(F)(F)F)C1=CN=C(S1)C(F)(F)F
InChiKey: FVQKQPWGUPWCHP-UHFFFAOYSA-N
InChi: InChI=1S/C13H5F6N3OS2/c14-12(15,16)5-1-2-6-7(3-5)25-11(21-6)22-9(23)8-4-20-10(24-8)13(17,18)19/h1-4H,(H,21,22,23)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Zamiri M, et al. 2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing. ACS Med Chem Lett. 2021 Oct 29;12(11):1818-1823.
Products are for research use only. Not for human use.
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