Description
AS-1763 is a Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton’s Tyrosine Kinase (BTK; IC50=0.85 nM). With significant efficacies in vivo tumor xenograft models, AS-1763 has advanced to phase 1 clinical trials. AS-1763 is a potent, selective, noncovalent, and orally available inhibitor of Bruton’s tyrosine kinase (IC50 = 0.85 nM).
Product information
CAS Number: 2227211-00-7
Molecular Weight: 578.64
Formula: C33H31FN6O3
Chemical Name: 2-(3-{2-amino-6-[1-(oxetan-3-yl)-1, 2, 3, 6-tetrahydropyridin-4-yl]-7H-pyrrolo[2, 3-d]pyrimidin-4-yl}-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoro-1, 2-dihydroisoquinolin-1-one
Smiles: NC1N=C2NC(=CC2=C(N=1)C1=CC=CC(=C1CO)N1C=CC2=CC(=CC(F)=C2C1=O)C1CC1)C1CCN(CC=1)C1COC1
InChiKey: LJODJUIHONTDMR-UHFFFAOYSA-N
InChi: InChI=1S/C33H31FN6O3/c34-26-13-21(18-4-5-18)12-20-8-11-40(32(42)29(20)26)28-3-1-2-23(25(28)15-41)30-24-14-27(36-31(24)38-33(35)37-30)19-6-9-39(10-7-19)22-16-43-17-22/h1-3,6,8,11-14,18,22,41H,4-5,7,9-10,15-17H2,(H3,35,36,37,38)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Kawahata W, et al. Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2021 Oct 14;64(19):14129-14141.
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