SOS1 PROTAC 9d


Catalog No. Size PriceQuantity
M33586-C Contact sales@xcessbio.com for quotation $100

Description

The compound 9d induced SOS1 degradation in various KRAS-driven cancer cells and displayed superior antiproliferation activity compared to the agonist itself,9d induced the highly cooperative SOS1−9d−VCB complex formation. 9d achieved significant tumor growth inhibition in the xenograft mouse model bearing NCI-H358 cells with a good safety profile. These results collectively provide good evidence of using PROTAC 9d to study SOS1 biological functions and to develop a new class of pan-KRAS inhibitors for clinical use.

Product information

Molecular Weight: 1051.79

Formula: C57H76ClFN10O4S

Chemical Name: (2S,4R)-1-[(2S)-2-{9-[4-(6-chloro-2-{2,6-diazaspiro[3.3]heptan-2-yl}-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-1,3-benzodiazol-4-yl)piperazin-1-yl]nonanamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

Smiles: CC(C)(C)[C@H](NC(=O)CCCCCCCCN1CCN(CC1)C1=CC(Cl)=CC2=C1N=C(N2CC1=CC(C)=C(F)C(C)=C1)N1CC2(CNC2)C1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1C=CC(=CC=1)C1SC=NC=1C

InChiKey: AZBRWXRYNYEDKG-VWELVXIZSA-N

InChi: InChI=1S/C57H76ClFN10O4S/c1-36-24-40(25-37(2)49(36)59)29-69-46-27-43(58)26-45(50(46)64-55(69)67-33-57(34-67)31-60-32-57)66-22-20-65(21-23-66)19-13-11-9-8-10-12-14-48(71)63-52(56(5,6)7)54(73)68-30-44(70)28-47(68)53(72)62-38(3)41-15-17-42(18-16-41)51-39(4)61-35-74-51/h15-18,24-27,35,38,44,47,52,60,70H,8-14,19-23,28-34H2,1-7H3,(H,62,72)(H,63,71)/t38-,44+,47-,52+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shelf Life: ≥12 months if stored properly.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed