Description
Difetarsone is an antiprotozoal agent. Various studies have shown it to be particularly effective against Trichuris trichiura, commonly known as the whipworm. It has also been used to treat Entamoeba histolytica infections. Prior to the drugs use in the early 1970s, there were few effective treatments for this infection. Difetarsone often has minor side effects, which include rashes, nausea and vomiting. It has also resulted in angioedema in at least one known case.
Product information
CAS Number: 3639-19-8
Molecular Weight: 460.15
Formula: C14H18As2N2O6
Chemical Name: ((ethane-1, 2-diylbis(azanediyl))bis(4, 1-phenylene))diarsonic acid
Smiles: O[As](O)(=O)C1C=CC(=CC=1)NCCNC1C=CC(=CC=1)[As](O)(O)=O
InChiKey: YQVALJGIKVYRNI-UHFFFAOYSA-N
InChi: InChI=1S/C14H18As2N2O6/c19-15(20,21)11-1-5-13(6-2-11)17-9-10-18-14-7-3-12(4-8-14)16(22,23)24/h1-8,17-18H,9-10H2,(H2,19,20,21)(H2,22,23,24)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Vandepitte J, Thienpont D. Trichuris infestations and difetarsone. Br Med J. 1972 Dec 2;4(5839):549. PubMed PMID: 4642803; PubMed Central PMCID: PMC1788733.
- Leary PM, Jones C, Douglas F, Boyd ST. Difetarsone in outpatient treatment of Trichuris trichiura infestation. Arch Dis Child. 1974 Jun;49(6):486-8. PubMed PMID: 4851370; PubMed Central PMCID: PMC1648795.
- Leary PM, Elsworth M, Maytham D, Jones C, Douglas F, Boyd S. Difetarsone in the treatment of Trichuris trichiura. S Afr Med J. 1973 Aug 11;47(31):1389. PubMed PMID: 4578732.
- Boyce JM, Fitzgerald TC, Gregg R. Difetarsone ('Bemarsal') and other anthelminthic drugs in the treatment of Trichuris trichiura (whipworm) infestation in a subnormality hospital. Br J Psychiatry. 1974 Feb;124(579):160-5. PubMed PMID: 4825661.
- Vandepitte J, Gatti F, Krubwa F, Thienpont D. Letter: Difetarsone in the treatment of Trichuris trichiura. S Afr Med J. 1973 Nov 24;47(46):2205. PubMed PMID: 4760912.
Products are for research use only. Not for human use.
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