Description
HSD-016 is a potent, selective, and efficacious 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor.
Product information
CAS Number: 946396-92-5
Molecular Weight: 514.46
Formula: C21H21F7N2O3S
Chemical Name: (R)-1, 1, 1-trifluoro-2-(3-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)phenyl)propan-2-ol
Smiles: C[C@@](O)(C1=CC(=CC=C1)S(=O)(=O)N1CCN(C[C@H]1C)C1=CC=C(F)C=C1C(F)(F)F)C(F)(F)F
InChiKey: ZWASRJHIEFYJGL-BFUOFWGJSA-N
InChi: InChI=1S/C21H21F7N2O3S/c1-13-12-29(18-7-6-15(22)11-17(18)20(23,24)25)8-9-30(13)34(32,33)16-5-3-4-14(10-16)19(2,31)21(26,27)28/h3-7,10-11,13,31H,8-9,12H2,1-2H3/t13-,19-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Wan ZK, Chenail E, Li HQ, Kendall C, Wang Y, Gingras S, Xiang J, Massefski WW, Mansour TS, Saiah E. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011 Sep 2;76(17):7048-55. doi: 10.1021/jo200958a. Epub 2011 Aug 2. PMID: 21736359.
Products are for research use only. Not for human use.
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