LDHA/PDKs-IN-1


Catalog No. Size PriceQuantity
M33924-C Contact sales@xcessbio.com for quotation $100

Description

LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases.

Product information

CAS Number: 2490699-40-4

Molecular Weight: 360.38

Formula: C19H21FN2O4

Smiles: CC1OC=CC(=O)C=1OCCN1CCN(CC1)C(=O)C1C=CC(F)=CC=1

InChiKey: AHYWOCBRZPCRAD-UHFFFAOYSA-N

InChi: InChI=1S/C19H21FN2O4/c1-14-18(17(23)6-12-25-14)26-13-11-21-7-9-22(10-8-21)19(24)15-2-4-16(20)5-3-15/h2-6,12H,7-11,13H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed