Description
GSK199 is a reversible and selective PAD4 inhibitor with an IC50 of 200 nM in the absence of calcium.
Product information
CAS Number: 1549811-53-1
Molecular Weight: 468.98
Formula: C24H29ClN6O2
Smiles: Cl.CN1C2C(=CC(=CC=2N=C1C1=CC2=CC=CN=C2N1CC)C(=O)N1C[C@H](N)CCC1)OC
InChiKey: KRGMIOKDGHBYQE-UNTBIKODSA-N
InChi: InChI=1S/C24H28N6O2.ClH/c1-4-30-19(12-15-7-5-9-26-22(15)30)23-27-18-11-16(13-20(32-3)21(18)28(23)2)24(31)29-10-6-8-17(25)14-29;/h5,7,9,11-13,17H,4,6,8,10,14,25H2,1-3H3;1H/t17-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Lewis HD, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11(3):189-91.
Products are for research use only. Not for human use.
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