Plasma kallikrein-IN-2


Catalog No. Size PriceQuantity
M33951-C Contact sales@xcessbio.com for quotation $100

Description

Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC50 of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research.

Product information

Molecular Weight: 629.03

Formula: C29H28ClF3N8O3

Smiles: CC1=NC(=CN=C1N1C[C@@H](C)[C@@H](C)C1=O)C(C)N1C=C(C=N1)NC(=O)C1=NC(=CN=C1CO)C1=C(C=CC(Cl)=C1F)C(F)F

InChiKey: JLHFPSCOGXXAFT-UIDSBSESSA-N

InChi: InChI=1S/C29H28ClF3N8O3/c1-13-10-40(29(44)14(13)2)27-15(3)37-20(8-35-27)16(4)41-11-17(7-36-41)38-28(43)25-22(12-42)34-9-21(39-25)23-18(26(32)33)5-6-19(30)24(23)31/h5-9,11,13-14,16,26,42H,10,12H2,1-4H3,(H,38,43)/t13-,14-,16?/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Ram W. Sabnis, et al. Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy. ACS Med Chem Lett. 2022 Mar 4;13(4):528-529.

Products are for research use only. Not for human use.

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