P2Y2R/GPR17 antagonist 1


Catalog No. Size PriceQuantity
M34036-C Contact sales@xcessbio.com for quotation $100

Description

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].

Product information

CAS Number: 2395016-49-4

Molecular Weight: 432.83

Formula: C19H13ClN2O6S

Smiles: [O-][N+](=O)C1=CC(=CC=C1)OS(=O)(=O)C1C=CC(=CC=1)NC(=O)C1=CC=CC=C1Cl

InChiKey: YGSIMJKEUKTDFX-UHFFFAOYSA-N

InChi: InChI=1S/C19H13ClN2O6S/c20-18-7-2-1-6-17(18)19(23)21-13-8-10-16(11-9-13)29(26,27)28-15-5-3-4-14(12-15)22(24)25/h1-12H,(H,21,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.

Products are for research use only. Not for human use.

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