Description
KS106 is a potent ALDH inhibitor with IC5os of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxicKS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1]
Product information
CAS Number: 2408477-50-7
Molecular Weight: 474.29
Formula: C18H15BrF3N3O2S
Smiles: Br.NC(=N)SCC1C=CC(CN2C3=CC=C(C=C3C(=O)C2=O)C(F)(F)F)=CC=1
InChiKey: AHVSKNDQJSDEMD-UHFFFAOYSA-N
InChi: InChI=1S/C18H14F3N3O2S.BrH/c19-18(20,21)12-5-6-14-13(7-12)15(25)16(26)24(14)8-10-1-3-11(4-2-10)9-27-17(22)23;/h1-7H,8-9H2,(H3,22,23);1H
Technical Data
Appearance: induces apoptosis and cell cycle arrest at the G2/M phase[1]
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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