Description
DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity.
Product information
CAS Number: 1386980-55-7
Molecular Weight: 624.52
Formula: C30H31Cl2N7O4
Chemical Name: N-{5-[(3-amino-1-phenylpropyl)carbamoyl]-2-chlorophenyl}-2-{8-oxa-3-azabicyclo[3.2.1]octan-3-yl}-7-oxo-7H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride
Smiles: Cl.NCCC(NC(=O)C1=CC(NC(=O)C2=CC3=CN=C(N=C3NC2=O)N2CC3CCC(C2)O3)=C(Cl)C=C1)C1C=CC=CC=1
InChiKey: XLHHYTUBPOMTDK-UHFFFAOYSA-N
InChi: InChI=1S/C30H30ClN7O4.ClH/c31-23-9-6-18(27(39)34-24(10-11-32)17-4-2-1-3-5-17)13-25(23)35-28(40)22-12-19-14-33-30(37-26(19)36-29(22)41)38-15-20-7-8-21(16-38)42-20;/h1-6,9,12-14,20-21,24H,7-8,10-11,15-16,32H2,(H,34,39)(H,35,40)(H,33,36,37,41);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 20.83 mg/mL (33.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO). H2O : < 0.1 mg/mL (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DYRKs-IN-1 hydrochloride (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM. DYRKs-IN-1 hydrochloride (Example 183) is a potent DYRKs inhibitor.
Products are for research use only. Not for human use.
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