HeE1-2Tyr


Catalog No. Size PriceQuantity
M34773-C Contact sales@xcessbio.com for quotation $100

Description

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro.

Product information

CAS Number: 2245195-67-7

Molecular Weight: 582.67

Formula: C33H30N2O6S

Chemical Name: (2S)-2-{[4-(cyclohexyloxy)-13-oxo-12-phenyl-8-thia-1-azatricyclo[7.4.0.0²,⁷]trideca-2,4,6,9,11-pentaen-10-yl]formamido}-3-(4-hydroxyphenyl)propanoic acid

Smiles: OC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1C=C(C2=CC=CC=C2)C(=O)N2C=1SC1=CC=C(C=C21)OC1CCCCC1

InChiKey: PTUWWNGMUPSKDC-MHZLTWQESA-N

InChi: InChI=1S/C33H30N2O6S/c36-22-13-11-20(12-14-22)17-27(33(39)40)34-30(37)26-19-25(21-7-3-1-4-8-21)31(38)35-28-18-24(15-16-29(28)42-32(26)35)41-23-9-5-2-6-10-23/h1,3-4,7-8,11-16,18-19,23,27,36H,2,5-6,9-10,17H2,(H,34,37)(H,39,40)/t27-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (171.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM. Additionally, upon infection of human HEK 293 cells (CC50 of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 μM. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV).

Products are for research use only. Not for human use.

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