Description
BGSN3 is a good substrate for the SNAP-tag? and H5 enzymes. The activities of SNAP-tag? and H5 enzymes on BGSN3 are reasonable (IC50=17.8 and 10 μM, respectively). BGSN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product information
CAS Number: 2996069-91-9
Molecular Weight: 381.39
Formula: C17H19N9O2
Chemical Name: N-[(4-{[(2-amino-9H-purin-6-yl)oxy]methyl}phenyl)methyl]-4-azidobutanamide
Smiles: [N-]=[N+]=NCCCC(=O)NCC1C=CC(COC2=NC(N)=NC3NC=NC=32)=CC=1
InChiKey: SRNLQFUHOQFWGK-UHFFFAOYSA-N
InChi: InChI=1S/C17H19N9O2/c18-17-24-15-14(21-10-22-15)16(25-17)28-9-12-5-3-11(4-6-12)8-20-13(27)2-1-7-23-26-19/h3-6,10H,1-2,7-9H2,(H,20,27)(H3,18,21,22,24,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (262.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SNAP-tag? is a powerful technology for the labelling of protein/enzymes by using benzyl-guanine (BG) derivatives as substrates. BGSN3 proved to be a good substrate for the direct immobilisation of these tags (SNAP-tag? and its relative thermo stable version, SsOGT-H5) on solid surfaces.
Products are for research use only. Not for human use.
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