Description
Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product information
Molecular Weight: 539.66
Formula: C25H49NO11
Chemical Name: 3,6,9,12,15,18,21,24,27,30,33-undecaoxahexatriacont-35-yn-1-amine
Smiles: C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
InChiKey: QJITZAWTLZAIGR-UHFFFAOYSA-N
InChi: InChI=1S/C25H49NO11/c1-2-4-27-6-8-29-10-12-31-14-16-33-18-20-35-22-24-37-25-23-36-21-19-34-17-15-32-13-11-30-9-7-28-5-3-26/h1H,3-26H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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