Description
Propargyl-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG12-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product information
Molecular Weight: 612.70
Formula: C28H52O14
Chemical Name: 4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxatetracont-39-ynoic acid
Smiles: C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
InChiKey: RUTNDSSFKULJTQ-UHFFFAOYSA-N
InChi: InChI=1S/C28H52O14/c1-2-4-31-6-8-33-10-12-35-14-16-37-18-20-39-22-24-41-26-27-42-25-23-40-21-19-38-17-15-36-13-11-34-9-7-32-5-3-28(29)30/h1H,3-27H2,(H,29,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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