Indomethacin-d4 Methyl Ester - CAS# 1217064-61-3


Catalog No. Size PriceQuantity
M34921-C Contact sales@xcessbio.com for quotation $100

Description

Indomethacin-d4 Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes.

Product information

CAS Number: 1217064-61-3

Molecular Weight: 375.84

Formula: C20H18ClNO4

Chemical Name: methyl 2-{1-[4-chloro(2,3,5,6-²H₄)benzoyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate

Smiles: [2H]C1C(C(=O)N2C3=CC=C(C=C3C(CC(=O)OC)=C2C)OC)=C([2H])C([2H])=C(Cl)C=1[2H]

InChiKey: OKHORWCUMZIORR-UGWFXTGHSA-N

InChi: InChI=1S/C20H18ClNO4/c1-12-16(11-19(23)26-3)17-10-15(25-2)8-9-18(17)22(12)20(24)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3/i4D,5D,6D,7D

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (266.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

Products are for research use only. Not for human use.

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