FTX-6058 hydrochloride - CAS# 2490676-19-0


Catalog No. Size PriceQuantity
M34922-C Contact sales@xcessbio.com for quotation $100

Description

FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 hydrochloride can induce HbF protein expression in cell and murine models. FTX-6058 hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia.

Product information

CAS Number: 2490676-19-0

Molecular Weight: 439.87

Formula: C22H19ClFN5O2

Chemical Name: (15R)-21-fluoro-10-(2-methylpyridin-3-yl)-13,17-dioxa-3,5,7,8-tetraazapentacyclo[13.6.1.0⁴,¹².0⁵,⁹.0¹⁸,²²]docosa-1(22),4(12),6,8,10,18,20-heptaene hydrochloride

Smiles: Cl.CC1=NC=CC=C1C1=CC2OC[C@H]3COC4=CC=C(F)C(CNC=2N2C=NN=C21)=C43

InChiKey: JOYSKAVINOJMDD-BTQNPOSSSA-N

InChi: InChI=1S/C22H18FN5O2.ClH/c1-12-14(3-2-6-24-12)15-7-19-22(28-11-26-27-21(15)28)25-8-16-17(23)4-5-18-20(16)13(9-29-18)10-30-19;/h2-7,11,13,25H,8-10H2,1H3;1H/t13-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

FTX-6058 hydrochloride inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models.

Products are for research use only. Not for human use.

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