Description
CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (from patent WO2019207463A1 example A93).
Product information
CAS Number: 2380321-50-4
Molecular Weight: 527.01
Formula: C22H28ClFN6O4S
Chemical Name: (3R,4R)-4-[(5-chloro-4-{4-fluoro-2-[(1R)-1-hydroxyethyl]-1-(propan-2-yl)-1H-1,3-benzodiazol-6-yl}pyrimidin-2-yl)amino]-1-methanesulfonylpiperidin-3-ol
Smiles: CC(C)N1C(=NC2=C(F)C=C(C=C12)C1=NC(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)=NC=C1Cl)[C@@H](C)O
InChiKey: KSCSDVHAZVSGAW-XHBKTUGNSA-N
InChi: InChI=1S/C22H28ClFN6O4S/c1-11(2)30-17-8-13(7-15(24)20(17)27-21(30)12(3)31)19-14(23)9-25-22(28-19)26-16-5-6-29(10-18(16)32)35(4,33)34/h7-9,11-12,16,18,31-32H,5-6,10H2,1-4H3,(H,25,26,28)/t12-,16-,18-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The CDK4 and CDK6 cell-based IC50s of CDK4/6-IN-5 in JEKO-1 and MV4-1 1 cells are 23.8 and 61.4 nM, respectively.
Products are for research use only. Not for human use.
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