Description
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product information
Molecular Weight: 883.04
Formula: C42H54N6O11S2
Chemical Name: N-[3-(6-methyl-1,2,4,5-tetrazin-3-yl)propyl]-1-({4-[3-(4-methylbenzenesulfonyl)-2-[(4-methylbenzenesulfonyl)methyl]propanoyl]phenyl}formamido)-3,6,9,12-tetraoxapentadecan-15-amide
Smiles: CC1N=NC(CCCNC(=O)CCOCCOCCOCCOCCNC(=O)C2C=CC(=CC=2)C(=O)C(CS(=O)(=O)C2C=CC(C)=CC=2)CS(=O)(=O)C2C=CC(C)=CC=2)=NN=1
InChiKey: DXHMDPDGPFQNJK-UHFFFAOYSA-N
InChi: InChI=1S/C42H54N6O11S2/c1-31-6-14-37(15-7-31)60(52,53)29-36(30-61(54,55)38-16-8-32(2)9-17-38)41(50)34-10-12-35(13-11-34)42(51)44-20-22-57-24-26-59-28-27-58-25-23-56-21-18-40(49)43-19-4-5-39-47-45-33(3)46-48-39/h6-17,36H,4-5,18-30H2,1-3H3,(H,43,49)(H,44,51)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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