(±)Eriodictyol, an ADAM17 inhibitor

(±)-Eriodictyol is a potent TRPV1 antagonist. (±)-Eriodictyol inhibits capsaicin-induced Ca2+ influx in synaptosomes and exhibits antinociceptive activity in animal models without affecting body temperature. (±)-Eriodictyol is also an antioxidant that protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. It is also a naturally-derived flavonoid that is orally bioavailable.

Product information

CAS Number: 4049-38-1

Molecular Weight: 288.25

Formula: C15H12O6

Synonym:

(+/-)-Eriodictyol

Huazhongilexone

MLS000877024

4049-38-1

5,7,3',4'-Tetrahydroxyflavanone

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one

2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one

SMR000440624

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-

Eriodictyol, (+/-)-

Eriodicytol

3',4',5,7-Tetrahydroxyflavanone

(1)-Eriodictyol

ERIODYCTOL

Flavanone, 3',4',5,7-tetrahydroxy-

(+/-)-3',4',5,7-Tetrahydroxyflavanone

(+/-)-5,7,3',4'-Tetrahydroxyflavanone

Oprea1_736075

BSPBio_002438

cid_11095

SPECTRUM1505145

CHEMBL307893

MEGxp0_000569

SCHEMBL2309591

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one

ACon1_000409

BDBM69393

Chemical Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one

Smiles: OC1C=C(O)C2C(=O)CC(OC=2C=1)C1=CC(O)=C(O)C=C1

InChiKey: SBHXYTNGIZCORC-UHFFFAOYSA-N

InChi: InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598
2. Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376

Products are for research use only. Not for human use.