Zofenopril (calcium)

Zofenopril, also known as SQ 26991, is a ACE inhibitor that protects the heart and helps reduce high blood pressure. Zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects. Zofenopril is a prodrug with zofenoprilat as the active metabolite.

Product information

CAS Number: 81938-43-4

Molecular Weight: 897.17

Formula: C44H44CaN2O8S4

Synonym:

SQ26991

Zoprace

Chemical Name: (2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid calcium

Smiles: [Ca+2].C[C@H](CSC(=O)C1C=CC=CC=1)C(=O)N1C[C@H](C[C@H]1C([O-])=O)SC1C=CC=CC=1.C[C@H](CSC(=O)C1C=CC=CC=1)C(=O)N1C[C@H](C[C@H]1C([O-])=O)SC1C=CC=CC=1

InChiKey: NSYUKKYYVFVMST-LETVYOFWSA-L

InChi: InChI=1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 2 mg/mL (4.46 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.
2. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63.

Products are for research use only. Not for human use.