Temocapril Hydrochloride


Catalog No. Size PriceQuantity
M9100-2 Solid 2 mg $90
M9100-10 Solid 10 mg $270

Description

Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).1 Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.1 In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.

Product information

CAS Number: 110221-44-8

Molecular Weight: 513.07

Formula: C23H29ClN2O5S2

Chemical Name: 2-[(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid hydrochloride

Smiles: Cl.CCOC(=O)[C@H](CCC1C=CC=CC=1)N[C@H]1CS[C@@H](CN(CC(O)=O)C1=O)C1=CC=CS1

InChiKey: XDDQNOKKZKHBIX-ASBZXGSUSA-N

InChi: InChI=1S/C23H28N2O5S2.ClH/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27;/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27);1H/t17-,18-,20-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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