Description
R1487 is an orally bioavailable and highly selective inhibitor of p38α with an ic50 value of 10 nM.
Product information
CAS Number: 449808-64-4
Molecular Weight: 424.83
Formula: C19H19ClF2N4O3
Chemical Name: 6-(2,4-difluorophenoxy)-8-methyl-2-[(oxan-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride
Smiles: Cl.CN1C(=O)C(=CC2=CN=C(NC3CCOCC3)N=C12)OC1C=CC(F)=CC=1F
InChiKey: RQHSAIGGUWVOBG-UHFFFAOYSA-N
InChi: InChI=1S/C19H18F2N4O3.ClH/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21;/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Solubility (25°C). DMSO: Insoluble. Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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