(S)-MRI-1867

(S)-MRI-1867 is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist. (S)-MRI-1867 ameliorates obesity-induced chronic kidney disease (CKD).

Product information

CAS Number: 1998760-00-1

Molecular Weight: 547.98

Formula: C25H21ClF3N5O2S

Chemical Name: (S)-3-(4-chlorophenyl)-N'-(1-iminoethyl)-4-phenyl-N-((4-(trifluoromethyl)phenyl)sulfonyl)-4, 5-dihydro-1H-pyrazole-1-carboximidamide

Smiles: CC(=N)N=C(NS(=O)(=O)C1C=CC(=CC=1)C(F)(F)F)N1C[C@@H](C(=N1)C1C=CC(Cl)=CC=1)C1C=CC=CC=1

InChiKey: NLXIJZHFEOSWPU-JOCHJYFZSA-N

InChi: InChI=1S/C25H21ClF3N5O2S/c1-16(30)31-24(33-37(35,36)21-13-9-19(10-14-21)25(27,28)29)34-15-22(17-5-3-2-4-6-17)23(32-34)18-7-11-20(26)12-8-18/h2-14,22H,15H2,1H3,(H2,30,31,33)/t22-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(S)-MRI-1867 can simultaneously inhibit CB1 receptors and iNOS in peripheral organs.

In Vivo:

(S)-MRI-1867 (3 mg/kg; p.o.; for 28 days) improves renal morphological and functional parameters in diet-induced obese mice.

Products are for research use only. Not for human use.