Cathepsin G Inhibitor I

IC50: 53 nM Cathepsin G (EC 3.4.21.20, chymotrypsin-like proteinase, neutral proteinase) is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. In vitro: Cathepsin G Inhibitor I shows reversible, competitive inhibition with IC50 and Ki values of 53 ± 12 (N = 10) and 63 ± 14 nM (N = 5), respectively. Another attribute of Cathepsin G Inhibitor I relates to its selectivity vs other serine proteases. It weakly inhibits chymotrypsin (Ki = 1.5 ± 0.2 μM), and poorly inhibits (<50% inhibition at 100 μM) thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase . In vivo: Cathepsin G Inhibitor I is currently in in-vitro investigation and no animal in vivo study is ongoing . Clinical trial: Cathepsin G Inhibitor I is currently in the preclinical development and no clinical trial is ongoing.

Product information

CAS Number: 429676-93-7

Molecular Weight: 620.63

Formula: C36H33N2O6P

Chemical Name: (2-{3-[(1-benzoylpiperidin-4-yl)(methyl)carbamoyl]naphthalen-2-yl}-1-(naphthalen-1-yl)-2-oxoethyl)phosphonic acid

Smiles: CN(C1CCN(CC1)C(=O)C1C=CC=CC=1)C(=O)C1=CC2=CC=CC=C2C=C1C(=O)C(C1=CC=CC2=CC=CC=C21)P(O)(O)=O

InChiKey: GNOZQRKYZJSIPZ-UHFFFAOYSA-N

InChi: InChI=1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.