(-)-Irofulven


Catalog No. Size PriceQuantity
M27660-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity.

Product information

CAS Number: 158440-71-2

Molecular Weight: 246.30

Formula: C15H18O3

Chemical Name: (6'R)-6'-hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethyl-6',7'-dihydrospiro[cyclopropane-1,5'-inden]-7'-one

Smiles: C[C@]1(O)C(=O)C2=CC(C)=C(CO)C2=C(C)C21CC2

InChiKey: NICJCIQSJJKZAH-AWEZNQCLSA-N

InChi: InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(-)-Irofulven (2.8 μM; 1 hour) induces p53-dependent cell cycle arrest. (-)-Irofulven (0.8 μM, 0.9 μM and 2.8 μM; 1 hour) induces CHK2 activation is related to p53 status in cells. (-)-Irofulven inhibits DNA replication and induces chromosome aberrations (breaks and radials).

In Vivo:

(-)-Irofulven (7 mg/kg; i.p; on days 1-5 and 8-12) produces a statistically significant increase in the median survival of mice bearing tumor cells.

Products are for research use only. Not for human use.

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