Domperidone


Catalog No. Size PriceQuantity
M9085-2 Solid 2 mg $80
M9085-10 Solid 10 mg $240

Description

Domperidone is used to relieve nausea and vomiting; to increase the transit of food through the stomach (that is, as a prokinetic agent via increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin. It is also used in scientific research to study the biological function of dopamine, an important neurotransmitter and hormone, in the body.

Product information

CAS Number: 57808-66-9

Molecular Weight: 425.91

Formula: C22H24ClN5O2

Synonym:

Motilium

Motillium

Motinorm

Costi

R33812

Chemical Name: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one

Smiles: O=C1NC2=CC(Cl)=CC=C2N1C1CCN(CCCN2C3=CC=CC=C3NC2=O)CC1

InChiKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N

InChi: InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (117.40 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Unlike Metoclopramide, Domperidone (R33812) does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier. Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported.

References:

  1. Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102(9):2036-2045.
  2. Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135(5):457-461.

Products are for research use only. Not for human use.

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