Azide-PEG4-VC-PAB-Doxorubicin

Azide-PEG4-VC-PAB-Doxorubicin is a drug-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody drug conjugate (ADC).

Product information

Molecular Weight: 1222.25

Formula: C57H75N9O21

Chemical Name: [4-[[(2S)-2-[[(2S)-2-[3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]phenyl]methyl N-[(2S, 3S, 4S, 6R)-3-hydroxy-2-methyl-6-[[(1S, 3S)-3, 5, 12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6, 11-dioxo-2, 4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]carbamate

Smiles: CC(C)[C@H](NC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])C(=O)N[C@@H](CCCNC(N)=O)C(=O)NC1=CC=C(COC(=O)N[C@H]2C[C@H](O[C@H]3C[C@@](O)(CC4=C(O)C5C(=O)C6=CC=CC(OC)=C6C(=O)C=5C(O)=C43)C(=O)CO)O[C@@H](C)[C@H]2O)C=C1

InChiKey: SRKJKGKXNXYJQK-KMKKCVBPSA-N

InChi: InChI=1S/C57H75N9O21/c1-30(2)47(65-41(69)14-17-81-19-21-83-23-24-84-22-20-82-18-16-61-66-59)54(76)63-36(8-6-15-60-55(58)77)53(75)62-33-12-10-32(11-13-33)29-85-56(78)64-37-25-42(86-31(3)48(37)70)87-39-27-57(79,40(68)28-67)26-35-44(39)52(74)46-45(50(35)72)49(71)34-7-5-9-38(80-4)43(34)51(46)73/h5,7,9-13,30-31,36-37,39,42,47-48,67,70,72,74,79H,6,8,14-29H2,1-4H3,(H,62,75)(H,63,76)(H,64,78)(H,65,69)(H3,58,60,77)/t31-,36-,37-,39-,42-,47-,48+,57-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.