SGD-1910

SGD-1910 is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala.

Product information

CAS Number: 1342820-51-2

Molecular Weight: 1089.20

Formula: C60H64N8O12

Chemical Name: 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(1S)-1-{[(1S)-1-({4-[(7S)-13-methoxy-12-(3-{[(7S)-13-methoxy-5-(4-methoxyphenyl)-2-oxo-3,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(10),4,8,11,13-pentaen-12-yl]oxy}propoxy)-2-oxo-3,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),4,8,10,12-pentaen-5-yl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]hexanamide

Smiles: CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](C)C(=O)NC1=CC=C(C=C1)C1C[C@H]2C=NC3=CC(OCCCOC4=CC5N=C[C@@H]6CC(=CN6C(=O)C=5C=C4OC)C4=CC=C(C=C4)OC)=C(C=C3C(=O)N2C=1)OC

InChiKey: TWQIMWSQDICMSE-DGCIIGOYSA-N

InChi: InChI=1S/C60H64N8O12/c1-35(2)56(65-53(69)11-8-7-9-22-66-54(70)20-21-55(66)71)58(73)63-36(3)57(72)64-41-16-12-37(13-17-41)39-25-42-31-61-47-29-51(49(77-5)27-45(47)59(74)67(42)33-39)79-23-10-24-80-52-30-48-46(28-50(52)78-6)60(75)68-34-40(26-43(68)32-62-48)38-14-18-44(76-4)19-15-38/h12-21,27-36,42-43,56H,7-11,22-26H2,1-6H3,(H,63,73)(H,64,72)(H,65,69)/t36-,42-,43-,56-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Products are for research use only. Not for human use.