Mutated EGFR-IN-2

Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity.

Product information

CAS Number: 2050906-97-1

Molecular Weight: 562.64

Formula: C29H35FN8O3

Chemical Name: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-({4-[5-fluoro-2-oxo-3-(propan-2-yl)-2, 3-dihydro-1H-1, 3-benzodiazol-1-yl]pyrimidin-2-yl}amino)-4-methoxyphenyl)prop-2-enamide

Smiles: CN(C)CCN(C)C1=CC(OC)=C(C=C1NC(=O)C=C)NC1=NC(=CC=N1)N1C(=O)N(C(C)C)C2=CC(F)=CC=C12

InChiKey: ZISPMWTYPDYENI-UHFFFAOYSA-N

InChi: InChI=1S/C29H35FN8O3/c1-8-27(39)32-20-16-21(25(41-7)17-23(20)36(6)14-13-35(4)5)33-28-31-12-11-26(34-28)38-22-10-9-19(30)15-24(22)37(18(2)3)29(38)40/h8-12,15-18H,1,13-14H2,2-7H3,(H,32,39)(H,31,33,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. 2, 4-di-(nitrogen containing group) substituted pyrimidine compound and preparation method and use thereof.

Products are for research use only. Not for human use.